Hypothalamic Hamartoma surgery in iran

دکتر محمد صادق مسعودی © ℗, دکتر الهه رضایی, دکتر علی اکبر اسدی پویا

Hypothalamic Hamartoma surgery in iran

کد: G-1034

نویسندگان: دکتر محمد صادق مسعودی © ℗, دکتر الهه رضایی, دکتر علی اکبر اسدی پویا

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خلاصه مقاله

Abstract Background: In 2020, the epilepsy center at Shiraz, Iran, embarked on establishing a surgical program for patients with hypothalamic hamartoma (HH). While minimally invasive techniques were preferred, they were not available in the region, leading to the adoption of open disconnection and resection surgery methods. This manuscript presents the outcomes of the HH surgery program at the center in the form of a case series. Methods: The study encompassed all patients diagnosed with HH, referred to the Shiraz Epilepsy Center due to drug-resistant epilepsy, and who underwent HH surgery between October 2020 and January 2023 at Namazi Hospital, Shiraz, Iran. Results: Seven patients were included in the study, all of whom experienced gelastic seizures. Total resection of HH was performed in four patients (57%), while the lesions were disconnected and partially resected in three other patients (43%). Following surgery, three patients (43%) became seizure-free, and three patients (43%) experienced a reduction of more than 50% in seizure frequency. Post-operative complications were observed in three patients (43%), with one patient (14.3%) experiencing permanent postoperative right hemiparesis. There were no cases of mortality, and five parents (71%) expressed satisfaction with the surgical outcomes. Conclusion: This study demonstrates the feasibility of conducting hypothalamic hamartoma surgery, even in centers with limited resources, through close collaboration between epileptology and neurosurgery teams. Successful outcomes can be achieved with careful planning, leveraging the expertise of the team members, and utilizing available resources effectively. Keywords: Brain; Epilepsy; Seizure; Surgery; Treatment.

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